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ID: ALA1136281

Journal: Bioorg Med Chem Lett

Title: Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents.

Authors: Kamal A, Ramesh G, Ramulu P, Srinivas O, Rehana T, Sheelu G.

Abstract: Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that possess cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.

CiteXplore: 14505647

DOI: 10.1016/s0960-894x(03)00743-1