Adenosine-anchored triphosphate subsite probing: distinguishing between HER-2 and HER-4 tyrosine protein kinases.

ID: ALA1136299

Journal: Bioorg Med Chem Lett

Title: Adenosine-anchored triphosphate subsite probing: distinguishing between HER-2 and HER-4 tyrosine protein kinases.

Authors: Liu F, Johnson EF, Austin DJ, Anderson KS.

Abstract: A strategy of full-site occupancy and stereospecific recognition in the triphosphate subsite was used to specifically inhibit two protein kinases HER-2 and HER-4 from the EGFR family. The SAR profiles of a panel of adenosine-anchored bicyclic heterocycles against HER-2 and HER-4 indicated that specificity can be derived for highly homologous protein kinases from stereospecific recognition in the triphosphate-subsite.

CiteXplore: 14505676

DOI: 10.1016/s0960-894x(03)00761-3

Patent ID: ┄