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ID: ALA1136332
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor.
Authors: Gallant M, Belley M, Carrière MC, Chateauneuf A, Denis D, Lachance N, Lamontagne S, Metters KM, Sawyer N, Slipetz D, Truchon JF, Labelle M.
Abstract: Potent and selective ligands for the human EP3 prostanoid receptor are described. Triaryl compounds bearing an ortho-substituted propionic acid moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinities of key compound on all eight human prostanoid receptors is reported.
CiteXplore: 14552786