Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs.

Basic Information

ID: ALA1136350

Journal: Bioorg Med Chem Lett

Title: Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs.

Authors: Chen JJ, Dewdney N, Lin X, Martin RL, Walker KA, Huang J, Chu F, Eugui E, Mirkovich A, Kim Y, Sarma K, Arzeno H, Van Wart HE.

Abstract: A novel series of TNF inhibitors was identified based on the screening of existing MMP inhibitor libraries. Further SAR optimization led to the discovery of a novel lead compound. Its synthesis, efficacy in experimental animal models, and pharmacokinetic data are discussed.

CiteXplore: 14592482

DOI: 10.1016/j.bmcl.2003.08.076

Patent ID: ┄