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ID: ALA1136353
Journal: Bioorg Med Chem Lett
Title: Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.
Authors: Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G.
Abstract: Heat shock protein 90 (Hsp90) is a molecular chaperone necessary for maintaining oncogenic transformation. There is substantial interest in developing novel agents that bind to the N-terminal of the chaperone. Here we report the synthesis and characterization of two fluorescent Hsp90 inhibitors and probe their use in an Hsp90 fluorescent polarization assay.
CiteXplore: 14592488