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ID: ALA1136354
Journal: Bioorg Med Chem Lett
Title: SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors.
Authors: Liu L, Stelmach JE, Natarajan SR, Chen MH, Singh SB, Schwartz CD, Fitzgerald CE, O'Keefe SJ, Zaller DM, Schmatz DM, Doherty JB.
Abstract: Development for a class of potent 3,4-dihydropyrido(3,2-d)pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3,4-dihydropyrido(3,2-d)pyrimidone analogues for the interaction with the hydrophobic pockets in p38 active site is also discussed.
CiteXplore: 14592489