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ID: ALA1136383
Journal: Bioorg Med Chem Lett
Title: New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation.
Authors: De Nanteuil G, Lila-Ambroise C, Rupin A, Vallez MO, Verbeuren TJ.
Abstract: The synthesis and activity of novel benzothiophene derivatives are described. In the t-Pa-induced fibrin clot lysis assay, several compounds inhibit the formation of the tPa-PAI-1 complex with submicromolar IC(50). This class of compounds potentially represents a new generation of antithrombotic-fibrinolytic agents.
CiteXplore: 12729646