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ID: ALA1136384
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and biological evaluation of hetaryl-nucleoside derivatives as inhibitors of chitin synthase.
Authors: Behr JB, Gourlain T, Helimi A, Guillerm G.
Abstract: We report here the design, synthesis and biological evaluation of new models of sugar analogues for chitin synthase. These UDP-GlcNAc mimetics associate a sugar-mimicking hetaryl group and uridine, linked with different pyrophosphate bioisosteres. The compounds displayed weak inhibition activity on chitin synthase and their antifungal potencies have been assayed against a large variety of pathogenic fungi.
CiteXplore: 12729648