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ID: ALA1136403
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of some novel 4'-thio-L-ribonucleosides with modified nucleobase moieties.
Authors: Pejanović V, Stokić Z, Stojanović B, Piperski V, Popsavin M, Popsavin V.
Abstract: 1,2,3,5-tetra-O-acetyl-4-thio-beta-L-ribofuranose (13) was synthesized by an improved five-step sequence starting from methyl alpha-D-lyxopyranoside. Compound 13 was then converted to the corresponding L-4'-thionucleosides 4-6 and 19 by a modified Vorbrüggen procedure. All of these nucleoside analogues were tested for their antitumour activity in vitro.
CiteXplore: 12749882