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ID: ALA1136408
Journal: Bioorg Med Chem Lett
Title: Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.
Authors: Hsieh HP, Liou JP, Lin YT, Mahindroo N, Chang JY, Yang YN, Chern SS, Tan UK, Chang CW, Chen TW, Lin CH, Chang YY, Wang CC.
Abstract: Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.
CiteXplore: 12467626