Document Report Card
Basic Information
ID: ALA1136419
Journal: Bioorg Med Chem Lett
Title: Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors.
Authors: Appendino G, Ligresti A, Minassi A, Daddario N, Bisogno T, Di Marzo V.
Abstract: Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB(1) receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB(1) receptors.
CiteXplore: 12467613