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ID: ALA1136425
Journal: Bioorg Med Chem Lett
Title: A novel metal-chelating inhibitor of protein farnesyltransferase.
Authors: Hamasaki A, Naka H, Tamanoi F, Umezawa K, Otsuka M.
Abstract: A novel metal chelator comprising a 4-(naphthalen-1-yl)pyridine and 2-aminoethanethiol was synthesized. This showed inhibitory activity against human protein farnesyltransferase with IC(50) 1.9 microM, induced morphological change in K-ras-NRK cells at 0.5 microg/mL and showed growth inhibition of K-ras-NRK cells with IC(50) 0.32 microg/mL.
CiteXplore: 12699746