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ID: ALA1136438

Journal: Bioorg Med Chem Lett

Title: Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants.

Authors: Perni RB, Britt SD, Court JC, Courtney LF, Deininger DD, Farmer LJ, Gates CA, Harbeson SL, Kim JL, Landro JA, Levin RB, Luong YP, O'Malley ET, Pitlik J, Rao BG, Schairer WC, Thomson JA, Tung RD, Van Drie JH, Wei Y.

Abstract: Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P1 and P2 inhibitor positions is discussed.

CiteXplore: 14592508

DOI: 10.1016/j.bmcl.2003.08.050