Document Report Card

Basic Information

ID: ALA1136447

Journal: Bioorg Med Chem Lett

Title: Biological investigation and structure-activity relationship studies on azadirone from Azadirachta indica A. Juss.

Authors: Nanduri S, Thunuguntla SS, Nyavanandi VK, Kasu S, Kumar PM, Ram PS, Rajagopal S, Kumar RA, Deevi DS, Rajagopalan R, Venkateswarlu A.

Abstract: Azadirone 1, a limonoidal constituent of Azadirachta indica is found to possess potent cytotoxic activity against a panel of human cancer cell lines in our in vitro studies. In vitro screening of a number of semi-synthetic analogues of 1 revealed that the alpha,beta-unsaturated enone moiety or its equivalent conjugated system in A-ring, C-7 acetyloxy/chloroacetyloxy or keto group in B-ring and the furan moiety are responsible for the activity of 1 and its analogues. Compound 1 and two of the semi-synthetic analogues 10 and 13 were found to possess good in vivo antitumor activity in modified hollow fiber animal models.

CiteXplore: 14592518

DOI: 10.1016/j.bmcl.2003.08.030