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ID: ALA1136467
Journal: Bioorg Med Chem Lett
Title: A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic.
Authors: Hattori K, Tabuchi S, Okitsu O, Taniguchi K.
Abstract: Synthetic method of a novel prostaglandin (PG) mimetic: FR181175 without PG skeleton are described. The key to success is creation of a chiral epoxide using Sharpless AD reaction with high ee yield. FR181157 shows high potency and agonist efficacy at the IP receptor and has good bioavailability.
CiteXplore: 14643308