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ID: ALA1136495
Journal: Bioorg Med Chem Lett
Title: Synthesis of new 3-arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity.
Authors: Cho WJ, Min SY, Le TN, Kim TS.
Abstract: To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.
CiteXplore: 14643344