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ID: ALA1136501

Journal: Bioorg Med Chem Lett

Title: Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.

Authors: Bymaster FP, Beedle EE, Findlay J, Gallagher PT, Krushinski JH, Mitchell S, Robertson DW, Thompson DC, Wallace L, Wong DT.

Abstract: A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for the treatment of depression.

CiteXplore: 14643350

DOI: 10.1016/j.bmcl.2003.08.079