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ID: ALA1136540
Journal: Bioorg Med Chem Lett
Title: Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Authors: Sawa M, Kurokawa K, Inoue Y, Kondo H, Yoshino K.
Abstract: A novel series of phosphonamide-based inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) was discovered by structural modification of tetrahydroisoquinoline derivative 1b, which was extremely weak inhibitor of TACE. (S)-Isomer at the phosphorus atom (7b) displayed potent inhibition for TACE, while selectivity sparing MMP-1, -3, and -9.
CiteXplore: 12781187