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ID: ALA1136541
Journal: Bioorg Med Chem Lett
Title: D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety.
Authors: Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Höffken HW.
Abstract: Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.
CiteXplore: 12781189