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ID: ALA1136543

Journal: Bioorg Med Chem Lett

Title: 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P2 elements for selectivity.

Authors: Setti EL, Davis D, Chung T, McCarter J.

Abstract: A novel series of 3,4-disubstituted azetidinones based inhibitors of the cysteine protease cathepsin K (Cat K) has been identified. Although not optimized, some of these compounds show at least 100-fold selectivity against other cathepsins. The use of cyclic moieties as P2 elements has proven to be crucial to achieve a high degree of selectivity.

CiteXplore: 12781193

DOI: 10.1016/s0960-894x(03)00304-4