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ID: ALA1136547
Journal: Bioorg Med Chem Lett
Title: 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors.
Authors: Hyup YH, Kwan JK, Kang SH, Noh MS, Ha JY, Kyu JK, Min KM, Hoon CH, Chung S.
Abstract: A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.
CiteXplore: 12565941