Document Report Card
Basic Information
ID: ALA1136559
Journal: Bioorg Med Chem Lett
Title: Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: a novel fungicidal lipopeptide-(I).
Authors: Wang W, Li Q, Hasvold L, Steiner B, Dickman DA, Ding H, Clairborne A, Chen HJ, Frost D, Goldman RC, Marsh K, Hui YH, Cox B, Nilius A, Balli D, Lartey P, Plattner JJ, Bennani YL.
Abstract: The echinocandin class of cyclic lipopeptides has been simplified to discover potent antifungal compounds. Namely A-192411 shows good in vitro activity against common pathogenic yeasts and has an acceptable safety window in vivo. Discovery, limited SAR, synthesis, biochemical and pharmaco-dynamic profiles of A-192411 are presented.
CiteXplore: 12565957