Document Report Card
Basic Information
ID: ALA1136568
Journal: Bioorg Med Chem Lett
Title: Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Authors: Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ.
Abstract: A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.
CiteXplore: 12565968