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ID: ALA1136573
Journal: Bioorg Med Chem Lett
Title: Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions.
Authors: Hegde VR, Puar MS, Dai P, Patel M, Gullo VP, Chan TM, Silver J, Pramanik BN, Jenh CH.
Abstract: Three condensed aromatic peptides SCH79235 (1), SCH79236 (2), and SCH204698 (3) were isolated from the fermentation broth of a Streptomycete microorganism. The structure of SCH204698 (3) was established by extensive NMR spectral data. All these compounds exhibited good activity against CD28-CD80 binding with an IC(50) of 0.42, 0.38 and 0.22 microM, respectively.
CiteXplore: 12565974