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ID: ALA1136577
Journal: Bioorg Med Chem Lett
Title: Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities.
Authors: Jew SS, Park BS, Lim DY, Kim MG, Chung IK, Kim JH, Hong CI, Kim JK, Park HJ, Lee JH, Park HG.
Abstract: Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.
CiteXplore: 12639541