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ID: ALA1136587
Journal: Bioorg Med Chem Lett
Title: Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.
Authors: Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ.
Abstract: Optimisation of the left-hand-side aryl moiety of a file compound screening hit against Staphylococcus aureus methionyl tRNA synthetase led to the identification of a series of potent nanomolar inhibitors. The best compounds showed excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics.
CiteXplore: 12639554