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ID: ALA1136597
Journal: Bioorg Med Chem Lett
Title: A structure-permeability study of small drug-like molecules.
Authors: Fichert T, Yazdanian M, Proudfoot JR.
Abstract: A systematic structure-permeability relationship study on a set of small drug-like molecules with log D values in the range -2.5 to 3 and carrying a diverse array of functionality reveals that the compounds with log D>0 and <3 are highly permeable. Surprisingly, several tetrazole derivatives were found to be substrates for efflux pump(s).
CiteXplore: 12639566