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ID: ALA1136653
Journal: Bioorg Med Chem Lett
Title: Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.
Authors: Billot X, Chateauneuf A, Chauret N, Denis D, Greig G, Mathieu MC, Metters KM, Slipetz DM, Young RN.
Abstract: Analogues of PGE(2) wherein the hydroxycyclopentanone ring has been replaced by a lactam have been prepared and evaluated as ligands for the EP(4) receptor. An optimized compound (19a) shows high potency and agonist efficacy at the EP(4) receptor and is highly selective over the other seven known prostaglandin receptors.
CiteXplore: 12643927