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ID: ALA1136656
Journal: Bioorg Med Chem Lett
Title: Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods.
Authors: Semple G, Andersson BM, Chhajlani V, Georgsson J, Johansson MJ, Rosenquist A, Swanson L.
Abstract: New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.
CiteXplore: 12643930