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ID: ALA1136657
Journal: Bioorg Med Chem Lett
Title: Novel ether derivatives of mannopeptimycin glycopeptide antibiotic.
Authors: Sum PE, How D, Torres N, Petersen PJ, Lenoy EB, Weiss WJ, Mansour TS.
Abstract: Novel ether derivatives of mannopeptimycin glycopeptide were synthesized to probe their SAR. Many of these derivatives exhibited potent antibacterial activity against methicillin resistant and vancomycin resistant strains. These ether derivatives were prepared via reductive ring cleavage of acetals to give a mixture of 6-O, 4-O, 3-O, and 2-O-ether isomers. Both 6-O-ether and 4-O-ether showed significantly enhanced antibacterial activity over the parent and the isovalerate esters.
CiteXplore: 12643932