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ID: ALA1136658
Journal: Bioorg Med Chem Lett
Title: Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease.
Authors: Zhang X, Schmitt AC, Jiang W, Wasserman Z, Decicco CP.
Abstract: Starting from a hexapeptide boronic acid lead, 3-amino bicyclic pyrazinones as novel beta-sheet dipeptide mimetics have been designed and synthesized. Side-chain manipulation of this scaffold generated a series of potent, nonpeptidic inhibitors of HCV NS3 protease.
CiteXplore: 12643933