Synthesis of low molecular weight compounds with complement inhibition activity.
Basic Information
ID: ALA1136673
Journal: Bioorg Med Chem Lett
Title: Synthesis of low molecular weight compounds with complement inhibition activity.
Authors: Master HE, Khan SI, Poojari KA.
Abstract: An attempt was made to synthesize a series of non-cytotoxic low molecular weight meta-substituted aromatic ethers (2-4, 5-7) and some of their bioisosteres (14-16) and to evaluate their activity on the activation of human complement (classical pathway) and their intrinsic hemolytic activity. The in vitro assay results of the inhibition of complement-mediated hemolysis by these analogues indicate that the aldehydic meta substituted aromatic ethers show inhibitory potency, while carboxylic acid meta substituted aromatic ethers show hemolytic activity. Some of the bioisosteres exhibit both inhibitory as well as hemolytic property.
CiteXplore: 12657256
DOI: 10.1016/s0960-894x(03)00112-4
Patent ID: ┄