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ID: ALA1136676
Journal: Bioorg Med Chem Lett
Title: The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.
Authors: Souto ML, Manríquez CP, Norte M, Leira F, Fernández JJ.
Abstract: This paper reports testing 15 polyether triterpenes with a squalene carbon skeleton for inhibitory effects on type 2A protein phosphatase. Two compounds, 16-hydroxydehydrothyrsiferol 10 and thyrsenol B 14, exhibited significant inhibitory action at a concentration of 10 microM. Comparison with thyrsiferyl-23-acetate 1 showed that a similar spatial disposition for the hydroxy group around C-15 or C-16 was the structural feature shared by these metabolites.
CiteXplore: 12657259