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ID: ALA1136678
Journal: Bioorg Med Chem Lett
Title: Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.
Authors: Watterson SH, Dhar TG, Ballentine SK, Shen Z, Barrish JC, Cheney D, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh DL, Iwanowicz EJ.
Abstract: The development of a series of novel indole-based inhibitors of 5'-inosine monophosphate dehydrogenase (IMPDH) is described. Various hydrogen bond acceptors at C-3 of the indole were explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are outlined.
CiteXplore: 12657262