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ID: ALA1136695
Journal: Bioorg Med Chem Lett
Title: Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.
Authors: Curtin ML, Florjancic AS, Cohen J, Gu WZ, Frost DJ, Muchmore SW, Sham HL.
Abstract: A series of imidazole-containing biphenyls was prepared and evaluated in vitro for inhibition of FTase and cellular Ras processing. Several of these analogues, such as 21, are potent inhibitors of FTase (<1nM), FTase/GGTase selective (>300-fold) and cellularly active ( CiteXplore: 12657284