Basic Information
ID: ALA1136701
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors.
Authors: Maw GN, Allerton CM, Gbekor E, Million WA.
Abstract: The SAR of a series of beta-carboline derived type 5 phosphodiesterase inhibitors has been explored and we have discovered compounds with excellent levels of PDE5 potency and selectivity over PDE6. However, the series exhibits low levels of selectivity over PDE11, a phosphodiesterase with unknown function.
CiteXplore: 12668004
DOI: 10.1016/s0960-894x(03)00159-8
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets