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ID: ALA1136712
Journal: Bioorg Med Chem Lett
Title: Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.
Authors: Tomczuk B, Lu T, Soll RM, Fedde C, Wang A, Murphy L, Crysler C, Dasgupta M, Eisennagel S, Spurlino J, Bone R.
Abstract: Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, highly potent, highly selective and orally bioavailable thrombin inhibitors using oxyguanidines as guanidine-mimetics.
CiteXplore: 12668020