Pyrrolopyrazinedione-based inhibitors of human hormone-sensitive lipase.

ID: ALA1136733

Journal: J Med Chem

Title: Pyrrolopyrazinedione-based inhibitors of human hormone-sensitive lipase.

Authors: Slee DH, Bhat AS, Nguyen TN, Kish M, Lundeen K, Newman MJ, McConnell SJ.

Abstract: The regulation of lipid metabolism and it's effect on glucose control and diabetes has received intense interest. Hormone-sensitive lipase (HSL) is a vital enzyme in lipid metabolism. A series of novel pyrrolopyrazinediones has been discovered that demonstrate submicromolar activity both in the enzyme assay and in a (14)C-emulsion assay employing cholesteryl oleate as a substrate as a secondary measure of HSL activity. These compounds represent novel inhibitors of the human HSL enzyme.

CiteXplore: 12646020

DOI: 10.1021/jm020460y

Patent ID: ┄