Document Report Card

ID: ALA1136735

Journal: J Med Chem

Title: Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands.

Authors: Descamps-François C, Yous S, Chavatte P, Audinot V, Bonnaud A, Boutin JA, Delagrange P, Bennejean C, Renard P, Lesieur D.

Abstract: We report the synthesis and binding properties at MT(1) and MT(2) receptors of the first example of agomelatine (N-[2-(7-methoxynaphth-1-yl)ethyl]acetamide) dimers in which two agomelatine moieties are linked together through their methoxy substituent by a polymethylene side chain according to the "bivalent ligand" approach. Some of these compounds behave as MT(1)-selective ligands. The most selective one (5) behaves as an antagonist.

CiteXplore: 12646022

DOI: 10.1021/jm0255872