Document Report Card

ID: ALA1136750

Journal: J Med Chem

Title: Synthesis and evaluation of a novel nonsteroidal-specific endothelial cell proliferation inhibitor.

Authors: Schmidt JM, Tremblay GB, Pagé M, Mercure J, Feher M, Dunn-Dufault R, Peter MG, Redden PR.

Abstract: The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substituted dibenzo[b,d]pyran-6-one scaffold, exemplified by structures 9a and 10, and report preliminary in vitro activity data indicating that this scaffold is a promising lead for the development of specific inhibitors of endothelial cell proliferation.

CiteXplore: 12672229

DOI: 10.1021/jm034007d