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ID: ALA1136813
Journal: Bioorg Med Chem Lett
Title: Bivalent biogenic amine reuptake inhibitors.
Authors: Fandrick K, Feng X, Janowsky A, Johnson R, Cashman JR.
Abstract: A series of aryltropane-based bivalent ligands was prepared and investigated for binding potency and for their ability to inhibit reuptake of human dopamine, serotonin and norepinephrine transporters. The bivalent ligand 4, comprised of linking an aryltropane by an octamethylene spacer showed high efficacy for the human dopamine transporter and had a discrimination ratio of 130.
CiteXplore: 12798324