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ID: ALA1136816
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics.
Authors: Sum PE, How D, Torres N, Petersen PJ, Ashcroft J, Graziani EI, Koehn FE, Mansour TS.
Abstract: A number of 6-O-ether and 4-O-ether derivatives of mannopeptimycin-alpha with different steric bulk and lipophilicity were synthesized for structure-activity relationship study. Novel iodo and bromo mannopeptimycin-alpha were also prepared. These compounds were synthesized via electrophilic aromatic substitution. Many of the new ether derivatives exhibited potent antibacterial activity against Gram-positive resistant strains including VRE, MRSA, and PRSP.
CiteXplore: 12873519