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ID: ALA1136831
Journal: Bioorg Med Chem Lett
Title: CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine.
Authors: Arvanitis AG, Arnold CR, Fitzgerald LW, Frietze WE, Olson RE, Gilligan PJ, Robertson DW.
Abstract: A series of imidazo[4,5-b]pyridines with a 7-(3-pyridyl) substituent is described as high affinity CRF receptor ligands. Individual analogues were synthesized from key intermediates obtained via palladium-catalyzed coupling of 3-pyridyl zinc or boronic acid organometallic intermediates with 2-benzyloxy-4-chloro-3-nitropyridine 12.
CiteXplore: 12482442