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ID: ALA1136917
Journal: Bioorg Med Chem Lett
Title: Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.
Authors: Tapadar S, He R, Luchini DN, Billadeau DD, Kozikowski AP.
Abstract: A series of hydroxamic acid based histone deacetylase inhibitors 6-15, containing an isoxazole moiety adjacent to the Zn-chelating hydroxamic acid, is reported herein. Some of these compounds showed nanomolar activity in the HDAC isoform inhibitory assay and exhibited micro molar inhibitory activity against five pancreatic cancer cell lines.
CiteXplore: 19419863