Basic Information
ID: ALA1136961
Journal: Bioorg Med Chem Lett
Title: Substituted tetrahydrocarbazoles with potent activity against human papillomaviruses.
Authors: Gudmundsson KS, Sebahar PR, Richardson LD, Catalano JG, Boggs SD, Spaltenstein A, Sethna PB, Brown KW, Harvey R, Romines KR.
Abstract: The synthesis and SAR of a series of substituted 1-aminotetrahydrocarbazoles with potent activity against human papillomaviruses are described. Synthetic approaches allowing for variation of the substitution pattern of the tetrahydrocarbazole are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity (W12 antiviral assay) in the low nanomolar range were identified and (1R)-6-bromo-N-[(1R)-1-phenylethyl]-2,3,4,9-tetrahydro-1H-carbazole-1-amine was selected for further evaluation.
CiteXplore: 19457669
DOI: 10.1016/j.bmcl.2009.05.003
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets