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ID: ALA1137046

Journal: Bioorg Med Chem Lett

Title: Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

Authors: Edmondson SD, Mastracchio A, Beconi M, Colwell LF, Habulihaz B, He H, Kumar S, Leiting B, Lyons KA, Mao A, Marsilio F, Patel RA, Wu JK, Zhu L, Thornberry NA, Weber AE, Parmee ER.

Abstract: In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50=1.9 microM). Optimization of 3 led to compound 37, which is among the most potent and selective DPP-IV inhibitors discovered to date.

CiteXplore: 15380217

DOI: 10.1016/j.bmcl.2004.07.056