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ID: ALA1137142
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists.
Authors: Arienzo R, Clark DE, Cramp S, Daly S, Dyke HJ, Lockey P, Norman D, Roach AG, Stuttle K, Tomlinson M, Wong M, Wren SP.
Abstract: A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors.
CiteXplore: 15225734