Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.
Basic Information
ID: ALA1137149
Journal: Bioorg Med Chem Lett
Title: Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.
Authors: Tu N, Link JT, Sorensen BK, Emery M, Grynfarb M, Goos-Nilsson A, Nguyen B.
Abstract: Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.
CiteXplore: 15261266
DOI: 10.1016/j.bmcl.2004.06.022
Patent ID: ┄
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