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ID: ALA1137167
Journal: Bioorg Med Chem Lett
Title: Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine.
Authors: Sharma V, Tepe JJ.
Abstract: The marine sponge metabolite hymenialdisine is a potent inhibitor of a variety of kinases including MEK-1, GSK-3 beta, and CK1. In addition, hymenialdisine and debromohymenialdisine exhibit inhibition of the G(2) cell cycle checkpoint at micromolar concentrations. We report herein the potent inhibition of cell cycle kinase Chk2 by the indolic-hymenialdisine indoloazepine 1 (IC(50)=8 nM).
CiteXplore: 15261294