Synthesis of an unusual branched-chain sugar, 5-C-methyl-L-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglyco...

ID: ALA1137173

Journal: Bioorg Med Chem Lett

Title: Synthesis of an unusual branched-chain sugar, 5-C-methyl-L-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglycoside antibiotics.

Authors: Wang J, Li J, Czyryca PG, Chang H, Kao J, Chang CW.

Abstract: The syntheses of a challenging branched-chain sugar and several L-sugars have been accomplished. Their application in studies of the antibacterial activity of pyranmycins is reported, which could provide new strategies for the future design of aminoglycoside antibiotics.

CiteXplore: 15357959

DOI: 10.1016/j.bmcl.2004.06.064

Patent ID: ┄